Pipestem dating definition
Physiologically, fibrosis acts to deposit connective tissue, which can interfere with or totally inhibit the normal architecture and function of the underlying organ or tissue.Fibrosis can be used to describe the pathological state of excess deposition of fibrous tissue, as well as the process of connective tissue deposition in healing. Bone size and cortical thickness indicate that the bone was from a robust adult, probably male.The surface is marked by equally spaced, shallow depressions that encircle the shaft.
However, the entire process, although necessary, can lead to a progressive irreversible fibrotic response if tissue injury is severe or repetitive, or if the wound healing response itself becomes deregulated.
Defined by the pathological accumulation of extracellular matrix (ECM) proteins, fibrosis results in scarring and thickening of the affected tissue, it is in essence an exaggerated wound healing response which interferes with normal organ function.
Fibrosis is similar to the process of scarring, in that both involve stimulated fibroblasts laying down connective tissue, including collagen and glycosaminoglycans.
This can be a reactive, benign, or pathological state.
In response to injury, this is called scarring, and if fibrosis arises from a single cell line, this is called a fibroma.
The process is initiated when immune cells such as macrophages release soluble factors that stimulate fibroblasts.